1/24/2024 0 Comments Stem cell banking![]() ![]() The most worthy of mention is that the rapid development and application of tissue-engineered cartilage (TEC), tissue-engineered meniscus (TEM), and tissue-engineered ligament (TEL) have greatly expanded the feasibility of the clinical application of stem cells in the management of sports injuries. In the past 20 years, great achievements have been made in the basic and clinical researches of stem cells and tissue engineering procedures in sports medicine. With the increasing cases of sports injury worldwide, issues for the treatments of articular cartilage injuries and the reconstruction of the structure and function of the torn meniscus and ligament need to be put on the agenda to promote recovery of motor function. Aging has a serious impact on all cells and tissues and can cause damages to the stem cell microenvironments. National Centre for Cell Science Cell RepositoryĪlthough stem cells can differentiate into different tissues and cells under certain induced microenvironments, they also tend to age under unstable storage conditions. ![]() ![]() Due to the complexity of building stem cell banks that requires the collaboration of ethics, sociology, medicine, bioinformatics, and many other fields, the domestic and foreign stem cell banks have not yet formed a unified principle or guideline for establishment and application. Founded in April 2010, Boyalife is the first and the only clinical-grade stem cell bank in China that has passed the AABB Standard of the United States, the NRL Standard of the World Health Organization, and the CAP Standard of the American Society of Pathology (Table (Table1). Established in 2015, Shanghai East Hospital Biobank is the first standardized biobank, integrating stem cell resources and other sample resources in China. Established in 2000, Peking University Stem Cell Research Center has become a prospective research institute for basic and clinical researches and a training center for stem cell biotechnology in China. At present, this center has established nearly 300 clinical-grade human embryonic stem cell lines with definite HLA matching types and nearly 2000 cell lines with different developmental potentials, laying a foundation for standardized and large-scale obtaining of functional cells for clinical application and the development of stem cell drugs. In 2017, it provided over 200 batches of stem cells for more than 20 research institutions and hospitals for pre-clinical researches or basic researches, actively promoting the translation of stem cells from laboratory to clinic. Among them, the National Stem Cell Resource Center established the first clinical-level stem cell bank and clinical-level embryonic stem cell line of China in 2007, and the establishment has actively promoted the sharing of stem cell resources. Since then, many stem cell banks have been established by governments or research institutions, such as the British Stem Cell Bank, the Korean NIH Stem Cell Bank, the Wicell Stem Cell Bank in the University of Wisconsin, and the RIKEN BioResource Center at RIKEN which are mainly for the storage and transfer of stem cell resources.Īlthough the researches and establishments of stem cell banks in China are late in getting started, the development momentum is rapid. The first international stem cell bank was established by the British Government in 2004. Since it is difficult to get most stem cells, the standardized production and preservation of stem cells through stem cell banks have become a mainstream trend. A stem cell bank is a platform for the large-scale collection, preparation, storage, provision, and research of stem cells, so it is also known as a “life bank”. ![]() Stem cells are a group of primitive cells with the potentials of self-renewal and multidirectional differentiation, and they are also known as “universal cells” and “seed cells”. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. ![]()
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